Genetics in vascular dementia
نویسندگان
چکیده
منابع مشابه
Genetics of subcortical vascular dementia
Subcortical vascular dementia or cerebral small vessel disease is a common cause of disability in the elderly. On magnetic resonance imaging the disease is manifested as white matter lesions, lacunes and microbleeds. Its etiology is complex, with age and hypertension as established risk factors. The heritability of white matter lesions is constantly high over different populations. Linkage stud...
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dementia is a syndrome encompassing many intellectual domains that can be broadly defined as an overall decline in intellectual function including difficulties with language, simple calculations, planning and judgment and motor skills as well as loss of memory. a genetic cause is identified in only a minority of patients, but patients and their family members are frequently concerned about the ...
متن کاملGenetics of vascular dementia – review from the ICVD working group
BACKGROUND Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms could improve our understanding of vascular dementia, leading to a potential translation of this knowledge to clinical practice. DISCUSSION In this review, we discuss what is cur...
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Cerebrovascular disease is the second leading cause of cognitive impairment in the elderly, either alone or in combination with Alzheimer's disease (AD). Vascular dementia (VaD) is heterogeneous in terms of both clinical phenotype and pathogenetic mechanisms. It may result from multiple cortical infarctions due to cerebral large vessel pathologies or to subcortical ischemic changes such as leuk...
متن کاملVascular cognitive impairment in dementia.
Vascular risk factors and cerebrovascular disease are common causes of dementia. Shared risk factors for vascular dementia and Alzheimer's disease, as well as frequent coexistence of these pathologies in cognitively impaired older people, suggests convergence of the aetiology, prevention and management of the commonest dementias affecting older people. In light of this understanding, the cognit...
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ژورنال
عنوان ژورنال: Future Neurology
سال: 2019
ISSN: 1479-6708,1748-6971
DOI: 10.2217/fnl-2018-0027